HUMAN NUCLEAR DICER RESTRICTS THE DELETERIOUS ACCUMULATION OF ENDOGENOUS DOUBLE STRAND RNA

Dicer is a central enzymatic player in RNA interference (RNAi) pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well-documented in mammals, its nuclear function remains obscure. Here we show that Dicer is present in both the nucle...

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Bibliographic Details
Main Authors: White, Eleanor, Schlackow, Margarita, Kamieniarz-Gdula, Kinga, Proudfoot, Nick J, Gullerova, Monika
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4129937/
https://ncbi.nlm.nih.gov/pubmed/24814348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2827
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