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The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer
HPP1 (hyperplastic polyposis protein 1), a tumor suppressor gene, is downregulated by promoter hypermethylation in a number of tumor types including colon cancer. c-Myc is also known to play a role in the suppression of HPP1 expression via binding to a promoter region cognate E-box site. The contrib...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128862/ https://ncbi.nlm.nih.gov/pubmed/24919179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29500 |
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