The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer

HPP1 (hyperplastic polyposis protein 1), a tumor suppressor gene, is downregulated by promoter hypermethylation in a number of tumor types including colon cancer. c-Myc is also known to play a role in the suppression of HPP1 expression via binding to a promoter region cognate E-box site. The contrib...

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Main Authors: Wang, Jian, Elahi, Abul, Ajidahun, Abidemi, Clark, Whalen, Hernandez, Jonathan, Achille, Alex, Hao, Ji-hui, Seto, Edward, Shibata, David
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128862/
https://ncbi.nlm.nih.gov/pubmed/24919179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29500
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