HPP1 Ectodomain Shedding is Mediated by ADAM17 and is Necessary for Tumor Suppression in Colon Cancer

BACKGROUND: Hyperplastic Polyposis Protein 1 (HPP1) encodes a tumor suppressive transmembrane cleavable Epidermal Growth Factor (EGF)-like ligand. It is unclear as to whether cleavage and shedding of HPP1 are essential steps in achieving its tumor suppressive properties. ADAM proteins are key player...

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Bibliographic Details
Published in:J Surg Res
Main Authors: Elahi, Abul, Ajidahun, Abidemi, Hendrick, Leah, Getun, Irina, Humphries, Leigh Ann, Hernandez, Jonathan, Shibata, David
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483406/
https://ncbi.nlm.nih.gov/pubmed/32450419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2020.04.010
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