Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

The interaction of the eukaryotic translation initiation factor eIF4E with the initiation factor eIF4G recruits the 40S ribosomal particle to the 5′ end of mRNAs, facilitates scanning to the AUG start codon, and is crucial for eukaryotic translation of nearly all genes. Efficient recruitment of the...

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Main Authors: Papadopoulos, Evangelos, Jenni, Simon, Kabha, Eihab, Takrouri, Khuloud J., Yi, Tingfang, Salvi, Nicola, Luna, Rafael E., Gavathiotis, Evripidis, Mahalingam, Poornachandran, Arthanari, Haribabu, Rodriguez-Mias, Ricard, Yefidoff-Freedman, Revital, Aktas, Bertal H., Chorev, Michael, Halperin, Jose A., Wagner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128100/
https://ncbi.nlm.nih.gov/pubmed/25049413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410250111
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