The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

BACKGROUND AND PURPOSE: Protease-activated receptor 2 (PAR2) is expressed on nociceptive neurons, and can sensitize transient receptor potential (TRP) ion channels to amplify neurogenic inflammation and pain. The mechanisms by which this occurs are not fully understood. PAR2 causes receptor-operated...

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Bibliografiske detaljer
Main Authors: Grace, M S, Lieu, T, Darby, B, Abogadie, F C, Veldhuis, N, Bunnett, N W, McIntyre, P
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128050/
https://ncbi.nlm.nih.gov/pubmed/24779362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12750
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