The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

BACKGROUND AND PURPOSE: Protease-activated receptor 2 (PAR2) is expressed on nociceptive neurons, and can sensitize transient receptor potential (TRP) ion channels to amplify neurogenic inflammation and pain. The mechanisms by which this occurs are not fully understood. PAR2 causes receptor-operated...

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Autores principales: Grace, M S, Lieu, T, Darby, B, Abogadie, F C, Veldhuis, N, Bunnett, N W, McIntyre, P
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128050/
https://ncbi.nlm.nih.gov/pubmed/24779362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12750
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