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Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR(2) and TRPV4
Serine proteases such as trypsin and mast cell tryptase cleave protease-activated receptor-2 (PAR(2)) at R(36)↓S(37) and reveal a tethered ligand that excites nociceptors, causing neurogenic inflammation and pain. Whether proteases that cleave PAR(2) at distinct sites are biased agonists that also i...
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175355/ https://ncbi.nlm.nih.gov/pubmed/25118282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.599712 |
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