Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR(2) and TRPV4

Serine proteases such as trypsin and mast cell tryptase cleave protease-activated receptor-2 (PAR(2)) at R(36)↓S(37) and reveal a tethered ligand that excites nociceptors, causing neurogenic inflammation and pain. Whether proteases that cleave PAR(2) at distinct sites are biased agonists that also i...

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Autori principali: Zhao, Peishen, Lieu, TinaMarie, Barlow, Nicholas, Metcalf, Matthew, Veldhuis, Nicholas A., Jensen, Dane D., Kocan, Martina, Sostegni, Silvia, Haerteis, Silke, Baraznenok, Vera, Henderson, Ian, Lindström, Erik, Guerrero-Alba, Raquel, Valdez-Morales, Eduardo E., Liedtke, Wolfgang, McIntyre, Peter, Vanner, Stephen J., Korbmacher, Christoph, Bunnett, Nigel W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175355/
https://ncbi.nlm.nih.gov/pubmed/25118282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.599712
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