Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation. Inappropriate ENaC activation by proteases may contribute to the pathophysiology of cystic fibrosis and could be involved in sodium retention and th...

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Bibliografiska uppgifter
Huvudupphovsmän: Haerteis, Silke, Krappitz, Matteus, Bertog, Marko, Krappitz, Annabel, Baraznenok, Vera, Henderson, Ian, Lindström, Erik, Murphy, Jane E., Bunnett, Nigel W., Korbmacher, Christoph
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer-Verlag 2012
Ämnen:
Ion Channels, Receptors and Transporters
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448907/
https://ncbi.nlm.nih.gov/pubmed/22864553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1138-3
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