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Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation. Inappropriate ENaC activation by proteases may contribute to the pathophysiology of cystic fibrosis and could be involved in sodium retention and th...

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Detalhes bibliográficos
Main Authors: Haerteis, Silke, Krappitz, Matteus, Bertog, Marko, Krappitz, Annabel, Baraznenok, Vera, Henderson, Ian, Lindström, Erik, Murphy, Jane E., Bunnett, Nigel W., Korbmacher, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448907/
https://ncbi.nlm.nih.gov/pubmed/22864553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1138-3
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