Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation. Inappropriate ENaC activation by proteases may contribute to the pathophysiology of cystic fibrosis and could be involved in sodium retention and th...

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Détails bibliographiques
Auteurs principaux: Haerteis, Silke, Krappitz, Matteus, Bertog, Marko, Krappitz, Annabel, Baraznenok, Vera, Henderson, Ian, Lindström, Erik, Murphy, Jane E., Bunnett, Nigel W., Korbmacher, Christoph
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2012
Sujets:
Ion Channels, Receptors and Transporters
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448907/
https://ncbi.nlm.nih.gov/pubmed/22864553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1138-3
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