Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation. Inappropriate ENaC activation by proteases may contribute to the pathophysiology of cystic fibrosis and could be involved in sodium retention and th...

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Dettagli Bibliografici
Autori principali: Haerteis, Silke, Krappitz, Matteus, Bertog, Marko, Krappitz, Annabel, Baraznenok, Vera, Henderson, Ian, Lindström, Erik, Murphy, Jane E., Bunnett, Nigel W., Korbmacher, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2012
Soggetti:
Ion Channels, Receptors and Transporters
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448907/
https://ncbi.nlm.nih.gov/pubmed/22864553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1138-3
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