Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites

Proteolytic activation is a unique feature of the epithelial sodium channel (ENaC). However, the underlying molecular mechanisms and the physiologically relevant proteases remain to be identified. The serine protease trypsin I can activate ENaC in vitro but is unlikely to be the physiologically rele...

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Detalhes bibliográficos
Main Authors: Haerteis, Silke, Krappitz, Annabel, Krappitz, Matteus, Murphy, Jane E., Bertog, Marko, Krueger, Bettina, Nacken, Regina, Chung, Hyunjae, Hollenberg, Morley D., Knecht, Wolfgang, Bunnett, Nigel W., Korbmacher, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081944/
https://ncbi.nlm.nih.gov/pubmed/24841206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.538470
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