Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

The mechanisms by which proteases activate the epithelial sodium channel (ENaC) are not yet fully understood. We investigated the effect of extracellular proteases on rat ENaC heterologously expressed in Xenopus laevis oocytes. Application of trypsin increased ENaC whole-oocyte currents by about 8-f...

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Библиографические подробности
Главные авторы: Diakov, Alexei, Bera, Katarzyna, Mokrushina, Marianna, Krueger, Bettina, Korbmacher, Christoph
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2008
Предметы:
Cellular
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614049/
https://ncbi.nlm.nih.gov/pubmed/18669538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.154435
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