Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

The mechanisms by which proteases activate the epithelial sodium channel (ENaC) are not yet fully understood. We investigated the effect of extracellular proteases on rat ENaC heterologously expressed in Xenopus laevis oocytes. Application of trypsin increased ENaC whole-oocyte currents by about 8-f...

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Detalhes bibliográficos
Main Authors: Diakov, Alexei, Bera, Katarzyna, Mokrushina, Marianna, Krueger, Bettina, Korbmacher, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Cellular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614049/
https://ncbi.nlm.nih.gov/pubmed/18669538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.154435
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