Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR(2)) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain

Proteases that cleave protease-activated receptor-2 (PAR(2)) at Arg(36)↓Ser(37) reveal a tethered ligand that binds to the cleaved receptor. PAR(2) activates transient receptor potential (TRP) channels of nociceptive neurons to induce neurogenic inflammation and pain. Although proteases that cleave...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhao, Peishen, Lieu, TinaMarie, Barlow, Nicholas, Sostegni, Silvia, Haerteis, Silke, Korbmacher, Christoph, Liedtke, Wolfgang, Jimenez-Vargas, Nestor N., Vanner, Stephen J., Bunnett, Nigel W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447962/
https://ncbi.nlm.nih.gov/pubmed/25878251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642736
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