Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR(2)) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain

Proteases that cleave protease-activated receptor-2 (PAR(2)) at Arg(36)↓Ser(37) reveal a tethered ligand that binds to the cleaved receptor. PAR(2) activates transient receptor potential (TRP) channels of nociceptive neurons to induce neurogenic inflammation and pain. Although proteases that cleave...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Zhao, Peishen, Lieu, TinaMarie, Barlow, Nicholas, Sostegni, Silvia, Haerteis, Silke, Korbmacher, Christoph, Liedtke, Wolfgang, Jimenez-Vargas, Nestor N., Vanner, Stephen J., Bunnett, Nigel W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Signal Transduction
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447962/
https://ncbi.nlm.nih.gov/pubmed/25878251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642736
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items