Stress-Induced Alternative Splice Forms of MDM2 and MDMX Modulate the p53-Pathway in Distinct Ways

MDM2 and MDMX are the chief negative regulators of the tumor-suppressor protein p53 and are essential for maintaining homeostasis within the cell. In response to genotoxic stress and also in several cancer types, MDM2 and MDMX are alternatively spliced. The splice variants MDM2-ALT1 and MDMX-ALT2 la...

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Detalhes bibliográficos
Main Authors: Jacob, Aishwarya G., Singh, Ravi K., Comiskey, Daniel F., Rouhier, Matthew F., Mohammad, Fuad, Bebee, Thomas W., Chandler, Dawn S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126728/
https://ncbi.nlm.nih.gov/pubmed/25105592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104444
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