Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage

Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isoform attributed with tumorigenic properties. However, the mechanisms underlying this event remain unclear. Here we explore MDM2 splicing regulation by utilizing a novel minigene that mimics endogenous MDM2...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Comiskey, Daniel F., Jacob, Aishwarya G., Singh, Ravi K., Tapia-Santos, Aixa S., Chandler, Dawn S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417157/
https://ncbi.nlm.nih.gov/pubmed/25845590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv223
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