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Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage
Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isoform attributed with tumorigenic properties. However, the mechanisms underlying this event remain unclear. Here we explore MDM2 splicing regulation by utilizing a novel minigene that mimics endogenous MDM2...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4417157/ https://ncbi.nlm.nih.gov/pubmed/25845590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv223 |
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