SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution

The sensitivity of massively-parallel sequencing has confirmed that most cancers are oligoclonal, with subpopulations of neoplastic cells harboring distinct mutations. A fine resolution view of this clonal architecture provides insight into tumor heterogeneity, evolution, and treatment response, all...

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Hlavní autoři: Miller, Christopher A., White, Brian S., Dees, Nathan D., Griffith, Malachi, Welch, John S., Griffith, Obi L., Vij, Ravi, Tomasson, Michael H., Graubert, Timothy A., Walter, Matthew J., Ellis, Matthew J., Schierding, William, DiPersio, John F., Ley, Timothy J., Mardis, Elaine R., Wilson, Richard K., Ding, Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125065/
https://ncbi.nlm.nih.gov/pubmed/25102416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003665
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