SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution

The sensitivity of massively-parallel sequencing has confirmed that most cancers are oligoclonal, with subpopulations of neoplastic cells harboring distinct mutations. A fine resolution view of this clonal architecture provides insight into tumor heterogeneity, evolution, and treatment response, all...

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Detalhes bibliográficos
Main Authors: Miller, Christopher A., White, Brian S., Dees, Nathan D., Griffith, Malachi, Welch, John S., Griffith, Obi L., Vij, Ravi, Tomasson, Michael H., Graubert, Timothy A., Walter, Matthew J., Ellis, Matthew J., Schierding, William, DiPersio, John F., Ley, Timothy J., Mardis, Elaine R., Wilson, Richard K., Ding, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125065/
https://ncbi.nlm.nih.gov/pubmed/25102416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003665
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