Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters

Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial metabolites, our knowledge of their diversity remains limited. Here, we used a novel algorithm to systematically identify BGCs in the extensive extant microbial sequencing data. Network analysis of the predicte...

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Main Authors: Cimermancic, Peter, Medema, Marnix H., Claesen, Jan, Kurita, Kenji, Wieland Brown, Laura C., Mavrommatis, Konstantinos, Pati, Amrita, Godfrey, Paul A., Koehrsen, Michael, Clardy, Jon, Birren, Bruce W., Takano, Eriko, Sali, Andrej, Linington, Roger G., Fischbach, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123684/
https://ncbi.nlm.nih.gov/pubmed/25036635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.06.034
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