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A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

Bacterial secondary metabolites are widely used as antibiotics, anticancer drugs, insecticides and food additives. Attempts to engineer their biosynthetic gene clusters (BGCs) to produce unnatural metabolites with improved properties are often frustrated by the unpredictability and complexity of the...

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Bibliografske podrobnosti
izdano v:PLoS Comput Biol
Main Authors: Medema, Marnix H., Cimermancic, Peter, Sali, Andrej, Takano, Eriko, Fischbach, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256081/
https://ncbi.nlm.nih.gov/pubmed/25474254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004016
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