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Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice
Mutation of tumor suppressor adenomatous polyposis coli (APC) initiates most colorectal cancers and chronic colitis increases risk. APC is a nucleo-cytoplasmic shuttling protein, best known for antagonizing Wnt signaling by forming a cytoplasmic complex that marks β-catenin for degradation. Using ou...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4123651/ https://ncbi.nlm.nih.gov/pubmed/24894865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu121 |
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