The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr(495) and Ser(1177)

NO production catalysed by eNOS (endothelial nitric-oxide synthase) plays an important role in the cardiovascular system. A variety of agonists activate eNOS through the Ser(1177) phosphorylation concomitant with Thr(495) dephosphorylation, resulting in increased ·NO production with a basal level of...

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Main Authors: Wu, Pei-Rung, Chen, Bo-Rui, Hsieh, Chi-Chun, Lin, Wei-Chung, Wu, Kenneth K., Hwu, Yeukuang, Chen, Pei-Feng
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2014
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122979/
https://ncbi.nlm.nih.gov/pubmed/24993645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140079
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