Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser(1177)/Thr(497) of endothelial nitric oxide synthase in diabetic mice

BACKGROUND: Azilsartan, an angiotensin II type 1 (AT1) receptor blocker (ARB), has a higher affinity for and slower dissociation from AT1 receptors and shows stronger inverse agonism compared to other ARBs. Possible benefits of azilsartan in diabetic vascular dysfunction have not been established. M...

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Detalhes bibliográficos
Main Authors: Matsumoto, Sachiko, Shimabukuro, Michio, Fukuda, Daiju, Soeki, Takeshi, Yamakawa, Ken, Masuzaki, Hiroaki, Sata, Masataka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916073/
https://ncbi.nlm.nih.gov/pubmed/24485356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-30
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