Lobe-Specific Calcium Binding in Calmodulin Regulates Endothelial Nitric Oxide Synthase Activation

BACKGROUND: Human endothelial nitric oxide synthase (eNOS) requires calcium-bound calmodulin (CaM) for electron transfer but the detailed mechanism remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Using a series of CaM mutants with E to Q substitution at the four calcium-binding sites, we found that...

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Detalhes bibliográficos
Main Authors: Wu, Pei-Rung, Kuo, Cheng-Chin, Yet, Shaw-Fang, Liou, Jun-Yang, Wu, Kenneth K., Chen, Pei-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387242/
https://ncbi.nlm.nih.gov/pubmed/22768143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039851
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