Rate, Affinity and Calcium Dependence of Nitric Oxide Synthase Isoform Binding to the Primary Physiological Regulator Calmodulin

Using interferometry based biosensors the binding and release of eNOS and nNOS from calmodulin (CaM) was measured. In both isoforms, binding to CaM is diffusion limited and within about three orders of magnitude of the Smoluchowski limit imposed by orientation independent collisions. This suggests t...

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Veröffentlicht in:FEBS J
Hauptverfasser: McMurry, Jonathan L., Chrestensen, Carol A., Scott, Israel M., Lee, Elijah W., Rahn, Aaron M., Johansen, Allan M., Forsberg, Brian J., Harris, Kyle D., Salerno, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641968/
https://ncbi.nlm.nih.gov/pubmed/22004458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08395.x
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