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The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr(495) and Ser(1177)
NO production catalysed by eNOS (endothelial nitric-oxide synthase) plays an important role in the cardiovascular system. A variety of agonists activate eNOS through the Ser(1177) phosphorylation concomitant with Thr(495) dephosphorylation, resulting in increased ·NO production with a basal level of...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Portland Press Ltd.
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4122979/ https://ncbi.nlm.nih.gov/pubmed/24993645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140079 |
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