Загрузка...

Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase λ

Although lamivudine and emtricitabine, two L-deoxycytidine analogs, have been widely used as antiviral drugs for years, a structural basis for D-stereoselectivity against L-dNTPs, enantiomers of natural nucleotides (D-dNTPs), by any DNA polymerase or reverse transcriptase has not been established du...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Vyas, Rajan, Zahurancik, Walter J., Suo, Zucai
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121797/
https://ncbi.nlm.nih.gov/pubmed/25015085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401286111
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!