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Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase ε holoenzyme

In eukaryotic DNA replication, DNA polymerase ε (Polε) is responsible for leading strand synthesis, whereas DNA polymerases α and δ synthesize the lagging strand. The human Polε (hPolε) holoenzyme is comprised of the catalytic p261 subunit and the noncatalytic p59, p17, and p12 small subunits. So fa...

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Pubblicato in:J Biol Chem
Autori principali: Zahurancik, Walter J., Suo, Zucai
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863874/
https://ncbi.nlm.nih.gov/pubmed/33051204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013903
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