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Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase ε holoenzyme
In eukaryotic DNA replication, DNA polymerase ε (Polε) is responsible for leading strand synthesis, whereas DNA polymerases α and δ synthesize the lagging strand. The human Polε (hPolε) holoenzyme is comprised of the catalytic p261 subunit and the noncatalytic p59, p17, and p12 small subunits. So fa...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7863874/ https://ncbi.nlm.nih.gov/pubmed/33051204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013903 |
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