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Kinetic Mechanism of DNA Polymerization Catalyzed by Human DNA Polymerase ε

Eukaryotes require highly accurate and processive DNA polymerases to ensure faithful and efficient replication of their genomes. DNA polymerase ε (Polε) has been shown to catalyze leading-strand DNA synthesis during replication in vivo, but little is known about the kinetic mechanism of polymerizati...

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Détails bibliographiques
Auteurs principaux: Zahurancik, Walter J., Klein, Seth J., Suo, Zucai
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859840/
https://ncbi.nlm.nih.gov/pubmed/24020356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400803v
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