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Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase λ
Although lamivudine and emtricitabine, two L-deoxycytidine analogs, have been widely used as antiviral drugs for years, a structural basis for D-stereoselectivity against L-dNTPs, enantiomers of natural nucleotides (D-dNTPs), by any DNA polymerase or reverse transcriptase has not been established du...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4121797/ https://ncbi.nlm.nih.gov/pubmed/25015085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401286111 |
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