DNA damage in germ cells induces immune response triggering systemic stress resistance

DNA damage responses have been well characterized in their cell-autonomous checkpoint functions leading to cell cycle arrest, senescence, and apoptosis (1). In contrast, systemic responses to tissue-specific genome instability remain poorly understood. In adult C. elegans worms germ cells undergo mi...

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Bibliographic Details
Main Authors: Ermolaeva, Maria A., Segref, Alexandra, Dakhovnik, Alexander, Ou, Hui-Ling, Schneider, Jennifer I., Utermöhlen, Olaf, Hoppe, Thorsten, Schumacher, Björn
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120807/
https://ncbi.nlm.nih.gov/pubmed/23975097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12452
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