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DNA damage responses and p53 in the aging process

The genome is constantly attacked by genotoxic insults. DNA damage has long been established to cause cancer development through its mutagenic consequences. Conversely, DNA damage is induced during radiation- and chemotherapy to drive cells into apoptosis or senescence as outcomes of the DNA damage...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ou, Hui-Ling, Schumacher, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839964/
https://ncbi.nlm.nih.gov/pubmed/29141944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-07-746396
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