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The innate immune system as mediator of systemic DNA damage responses

DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow time for DNA repair, or induce cellular senescence and apoptosis to eliminate damaged cells.(2) In contrast to cell-autonomous DNA damag...

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Détails bibliographiques
Auteurs principaux: Ermolaeva, Maria, Schumacher, Björn
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922787/
https://ncbi.nlm.nih.gov/pubmed/25210580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cib.26926
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