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The innate immune system as mediator of systemic DNA damage responses
DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow time for DNA repair, or induce cellular senescence and apoptosis to eliminate damaged cells.(2) In contrast to cell-autonomous DNA damag...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3922787/ https://ncbi.nlm.nih.gov/pubmed/25210580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cib.26926 |
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