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The innate immune system as mediator of systemic DNA damage responses

DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow time for DNA repair, or induce cellular senescence and apoptosis to eliminate damaged cells.(2) In contrast to cell-autonomous DNA damag...

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Bibliografiska uppgifter
Huvudupphovsmän: Ermolaeva, Maria, Schumacher, Björn
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922787/
https://ncbi.nlm.nih.gov/pubmed/25210580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cib.26926
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