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Pentapeptide Boronic Acid Inhibitors of Mycobacterium tuberculosis MycP(1) Protease
Mycosin protease-1 (MycP(1)) cleaves ESX secretion-associated protein B (EspB) that is a virulence factor of Mycobacterium tuberculosis, and accommodates an octapeptide, AVKAASLG, as a short peptide substrate. Because peptidoboronic acids are known inhibitors of serine proteases, the synthesis and b...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4120117/ https://ncbi.nlm.nih.gov/pubmed/24915878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.05.056 |
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