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Pentapeptide Boronic Acid Inhibitors of Mycobacterium tuberculosis MycP(1) Protease

Mycosin protease-1 (MycP(1)) cleaves ESX secretion-associated protein B (EspB) that is a virulence factor of Mycobacterium tuberculosis, and accommodates an octapeptide, AVKAASLG, as a short peptide substrate. Because peptidoboronic acids are known inhibitors of serine proteases, the synthesis and b...

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Bibliografiske detaljer
Main Authors: Frasinyuk, Mykhaylo S., Kwiatkowski, Stefan, Wagner, Jonathan M., Evans, Timothy J., Reed, Robert W., Korotkov, Konstantin V., Watt, David S.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120117/
https://ncbi.nlm.nih.gov/pubmed/24915878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.05.056
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