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Solution Structure and Refolding of the Mycobacterium tuberculosis Pentapeptide Repeat Protein MfpA

The pentapeptide repeat is a recently discovered protein fold. Mycobacterium tuberculosis MfpA is a founding member of the pentapeptide repeat protein (PRP) family that confers resistance to the antibiotic fluoroquinolone by binding to DNA gyrase and inhibiting its activity. The size, shape, and sur...

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Bibliographic Details
Main Authors: Khrapunov, Sergei, Cheng, Huiyong, Hegde, Subray, Blanchard, John, Brenowitz, Michael
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606005/
https://ncbi.nlm.nih.gov/pubmed/18977756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804702200
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