Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases

The generation of genetically modified animals is important for both research and commercial purposes. The rat is an important model organism that until recently lacked efficient genetic engineering tools. Sequence-specific nucleases, such as ZFNs, TALE nucleases, and CRISPR/Cas9 have allowed the cr...

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Main Authors: Remy, Séverine, Tesson, Laurent, Menoret, Séverine, Usal, Claire, De Cian, Anne, Thepenier, Virginie, Thinard, Reynald, Baron, Daniel, Charpentier, Marine, Renaud, Jean-Baptiste, Buelow, Roland, Cost, Gregory J., Giovannangeli, Carine, Fraichard, Alexandre, Concordet, Jean-Paul, Anegon, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
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Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120090/
https://ncbi.nlm.nih.gov/pubmed/24989021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.171538.113
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