Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

BAC transgenic mammalian systems offer an important platform for recapitulating human gene expression and disease modeling. While the larger body mass, and greater genetic and physiologic similarity to humans render rats well suited for reproducing human immune diseases and evaluating therapeutic st...

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Pubblicato in:Sci Rep
Autori principali: Jung, Chris J., Ménoret, Séverine, Brusselle, Lucas, Tesson, Laurent, Usal, Claire, Chenouard, Vanessa, Remy, Séverine, Ouisse, Laure-Hélène, Poirier, Nicolas, Vanhove, Bernard, de Jong, Pieter J., Anegon, Ignacio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987655/
https://ncbi.nlm.nih.gov/pubmed/27530248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31455
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