Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

BAC transgenic mammalian systems offer an important platform for recapitulating human gene expression and disease modeling. While the larger body mass, and greater genetic and physiologic similarity to humans render rats well suited for reproducing human immune diseases and evaluating therapeutic st...

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Udgivet i:Sci Rep
Main Authors: Jung, Chris J., Ménoret, Séverine, Brusselle, Lucas, Tesson, Laurent, Usal, Claire, Chenouard, Vanessa, Remy, Séverine, Ouisse, Laure-Hélène, Poirier, Nicolas, Vanhove, Bernard, de Jong, Pieter J., Anegon, Ignacio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987655/
https://ncbi.nlm.nih.gov/pubmed/27530248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31455
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