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Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5
BACKGROUND: The clinical benefits of opioid drugs are counteracted by the development of tolerance and addiction. Here, we provide in vivo evidence for the involvement of G protein-coupled receptor kinases (GRKs) in opioid dependence in addition to their roles in agonist-selective μ-opioid receptor...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119866/ https://ncbi.nlm.nih.gov/pubmed/24629717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.01.021 |
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