GRK2 Protein-mediated Transphosphorylation Contributes to Loss of Function of μ-Opioid Receptors Induced by Neuropeptide FF (NPFF(2)) Receptors

Neuropeptide FF (NPFF) interacts with specific receptors to modulate opioid functions in the central nervous system. On dissociated neurons and neuroblastoma cells (SH-SY5Y) transfected with NPFF receptors, NPFF acts as a functional antagonist of μ-opioid (MOP) receptors by attenuating the opioid-in...

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Detalhes bibliográficos
Main Authors: Moulédous, Lionel, Froment, Carine, Dauvillier, Stéphanie, Burlet-Schiltz, Odile, Zajac, Jean-Marie, Mollereau, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339982/
https://ncbi.nlm.nih.gov/pubmed/22375000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314617
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