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Loss of Morphine Reward and Dependence in Mice Lacking G Protein-Coupled Receptor Kinase 5

BACKGROUND: The clinical benefits of opioid drugs are counteracted by the development of tolerance and addiction. Here, we provide in vivo evidence for the involvement of G protein-coupled receptor kinases (GRKs) in opioid dependence in addition to their roles in agonist-selective μ-opioid receptor...

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Bibliografski detalji
Glavni autori: Glück, Laura, Loktev, Anastasia, Moulédous, Lionel, Mollereau, Catherine, Law, Ping-Yee, Schulz, Stefan
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119866/
https://ncbi.nlm.nih.gov/pubmed/24629717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.01.021
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