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Heparin stability by determining unsubstituted amino groups using HILIC-MS
The thermal instability of the anticoagulant heparin is associated, in part, with the solvolytic loss of N-sulfo groups. This study describes a new method to assess the increased content of unsubstituted amino groups present in thermally-stressed and autoclave-sterilized heparin formulations. N-acet...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119833/ https://ncbi.nlm.nih.gov/pubmed/24909446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2014.05.028 |
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