Heparin stability by determining unsubstituted amino groups using HILIC-MS

The thermal instability of the anticoagulant heparin is associated, in part, with the solvolytic loss of N-sulfo groups. This study describes a new method to assess the increased content of unsubstituted amino groups present in thermally-stressed and autoclave-sterilized heparin formulations. N-acet...

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Detaylı Bibliyografya
Asıl Yazarlar: Fu, Li, Li, Lingyun, Cai, Chao, Li, Guoyun, Zhang, Fuming, Linhardt, Robert J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119833/
https://ncbi.nlm.nih.gov/pubmed/24909446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2014.05.028
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