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Bayesian designs of phase II oncology trials to select maximum effective dose assuming monotonic dose-response relationship

BACKGROUND: For many molecularly targeted agents, the probability of response may be assumed to either increase or increase and then plateau in the tested dose range. Therefore, identifying the maximum effective dose, defined as the lowest dose that achieves a pre-specified target response and beyon...

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Hlavní autoři: Guo, Beibei, Li, Yisheng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119476/
https://ncbi.nlm.nih.gov/pubmed/25074481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-14-95
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