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Bayesian designs of phase II oncology trials to select maximum effective dose assuming monotonic dose-response relationship

BACKGROUND: For many molecularly targeted agents, the probability of response may be assumed to either increase or increase and then plateau in the tested dose range. Therefore, identifying the maximum effective dose, defined as the lowest dose that achieves a pre-specified target response and beyon...

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書目詳細資料
Main Authors: Guo, Beibei, Li, Yisheng
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119476/
https://ncbi.nlm.nih.gov/pubmed/25074481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-14-95
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