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Catch-and-Hold Activation of Muscle Acetylcholine Receptors Having Transmitter Binding Site Mutations
Agonists turn on receptors because their target sites have a higher affinity in the active versus resting conformation of the protein. We used single-channel electrophysiology to measure the lower-affinity (LA) and higher-affinity (HA) equilibrium dissociation constants for acetylcholine in adult-ty...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119287/ https://ncbi.nlm.nih.gov/pubmed/24988344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.04.057 |
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