Catch-and-Hold Activation of Muscle Acetylcholine Receptors Having Transmitter Binding Site Mutations

Agonists turn on receptors because their target sites have a higher affinity in the active versus resting conformation of the protein. We used single-channel electrophysiology to measure the lower-affinity (LA) and higher-affinity (HA) equilibrium dissociation constants for acetylcholine in adult-ty...

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Bibliographische Detailangaben
Hauptverfasser: Purohit, Prasad, Bruhova, Iva, Gupta, Shaweta, Auerbach, Anthony
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2014
Schlagworte:
Channels and Transporters
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119287/
https://ncbi.nlm.nih.gov/pubmed/24988344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.04.057
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